George R. Minot AKA George Richards Minot Born: 2-Dec-1885 Birthplace: Boston, MA Died: 25-Feb-1950 Location of death: Brookline, MA Cause of death: unspecified
Gender: Male Religion: Unitarian Race or Ethnicity: White Sexual orientation: Straight Occupation: Doctor Nationality: United States Executive summary: Liver therapy for pernicious anemia George Minot researched numerous blood disorders, including leukemia, and made his most famous discovery by isolating a treatment for pernicious anemia. Though we now think of this as a relatively minor ailment, in the early 20th century it was a deadly disease. Minot meticulously recorded the diets of patients with anemia, seeking a unifying factor that might lead to a cause and a cure. Following up on the research of George H. Whipple, Minot and his colleague William P. Murphy fed liver to patients suffering from pernicious anemia -- basically, feeding them liver until they could stand to eat no more.
Their findings showed that the ingestion of one half-pound of liver daily effectively reversed the course of the disease. In collaboration with chemist Edwin Cohn, Minot and Murphy then formulated an effective liver extract, and showed that a very small quantity of this extract, administered intravenously, had the same effect as eating huge quantities of liver. This became the standard treatment for pernicious anemia until Vitamin B-12 was isolated, two decades later. For their life-saving work, Minot, Murphy, and Whipple shared the 1934 Nobel Prize in Physiology or Medicine.
He married Marian Linzee Weld, who had been his next-door neighbor in childhood. A member of the Boston blueblood Minot family, he was distantly related to 1890s Secretary of State Richard Olney and 1990s Massachusetts Governor Bill Weld. Father: James Jackson Minot (physician, b. 1853, d. 1938) Mother: Elizabeth Whitney Minot (b. 1860, d. 1903) Brother: James Jackson Minot Jr (stockbroker, b. 17-Nov-1891, d. 5-Sep-1985) Brother: Henry Whitney Minot (b. 6-Feb-1896, 15-Apr-1971) Wife: Marian Linzee Weld (b. 17-May-1890, m. 29-Jun-1915, d. 1979) Daughter: Marian Linzee Minot (b. 6-Oct-1918) Daughter: Elizabeth Whitney Minot (b. 4-Dec-1920) Son: Charles Sedgwick Minot (physician, b. 18-Mar-1930)
University: BA, Harvard University (1908) Medical School: MD, Harvard Medical School (1912) Teacher: Medicine, Johns Hopkins University (1913-15) Teacher: Medicine, Harvard Medical School (1915-28) Professor: Medicine, Harvard Medical School (1928-47)
Nobel Prize for Medicine 1934 (with George H. Whipple and William P. Murphy) Risk Factors: Diabetes
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