William H. Stein AKA William Howard Stein Born: 25-Jun-1911 Birthplace: New York City Died: 2-Feb-1980 Location of death: New York City Cause of death: Heart Failure
Gender: Male Religion: Jewish Race or Ethnicity: White Sexual orientation: Straight Occupation: Chemist Nationality: United States Executive summary: Amino-acid analyzer Military service: Office of Scientific Research Development (1942-45) American scientist William H. Stein is best known for his studies of the enzyme ribonuclease (RNase), and for work showing how proteins comprised of the same amino acids can have very different characteristics and functions. In 1958 Stein and his colleague and frequent collaborator Stanford Moore developed the first means for automated amino acid analysis, and in 1963 they became the first scientists to lay out the structure and sequence of an enzyme.
Stein was afflicted with Guillain-Barré Syndrome, an autoimmune disease of the peripheral nerves, which left him paralyzed after about 1971. He became the first quadriplegic Nobel laureate when he won the Nobel Prize for Chemistry in 1972, sharing the honor with Moore and with Christian Anfinsen, another scientist who had conducted related studies of RNase at Harvard. Stein's scientific work was of course limited for the last decade of his life, but he hosted several informal seminars on scientific topics in his his home, and occasionally visited his office in his wheelchair until his death in 1980. His obituary for the National Academy of Sciences was written by his friend, Moore. Father: Fred Michael Stein (banker) Mother: Beatrice Borg Stein (children's rights activist, m. 26-Nov-1903) Brother: Fred Micheal Stein, Jr. (health advocate, b. 9-Jul-1905, d. 22-Aug-1997) Sister: Cecilia Borg Stein Cullman (children's rights activist, b. 7-Apr-1914) Wife: Phoebe Hockstader (b. circa 1914, m. 1936, d. 1989, three sons) Son: William H. Stein, Jr. (b. circa 1937) Son: David F. Stein (b. circa 1939) Son: Robert J. Stein (b. circa 1944)
High School: Lincoln School of Teachers College, New York City (attended, 1926-27) High School: Phillips Exeter Academy (1929) University: BS Chemistry, Harvard University (1933) University: MS Chemistry, Columbia University (1935) University: PhD, Columbia University (1938) Scholar: Rockefeller Institute for Medical Research (1938-52) Professor: Biochemistry, Rockefeller Institute for Medical Research (1952-65) Professor: Biochemistry, Rockefeller University (1965-82)
ACS Award in Chromatography and Electrophoresis 1964 (with Stanford Moore)
Nobel Prize for Chemistry 1972 (with Christian Anfinsen and Stanford Moore) ACS Theodore William Richards Medal 1972 (with Stanford Moore)
CRC Linderstrĝm-Lang Medal 1972 (with Stanford Moore)
American Academy of Arts and Sciences American Association for the Advancement of Science American Chemical Society American Society for Biochemistry and Molecular Biology Biochemical Society
Harvey Society
Journal of Biological Chemistry Editorial Committee, 1955-62
Journal of Biological Chemistry Editorial Board, 1962-64
Journal of Biological Chemistry Associate Editor, 1964-68
Journal of Biological Chemistry Editor, 1968-71
National Academy of Sciences New York Academy of Sciences Sigma Xi Scientific Research Society National Institutes of Health Paralyzed 1971 until his death, from effects of Guillain-Barré Syndrome Heart Attack 2-Feb-1980 (fatal) Jewish Ancestry
Risk Factors: Guillain-Barré Syndrome
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